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Testosterone can enhance the anticoagulant action of warfarin.[eighteen] Major bleeding has actually been noted in certain patients with this drug-drug conversation. Although the system is unclear, testosterone may reduce procoagulant components. Reduction of warfarin dosage can be needed if testosterone therapy is coadministered.
32 The clinical significance of the conversation is unclear at this time. Though details are certainly not out there, the same response may well come about with voriconazole. Both fluconazole and voriconazole are inhibitors of CYP3A4, the hepatic microsomal isoenzyme responsible for metabolism of testosterone.[33]
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